Alcohol should never be mixed with an antidepressant medication like Prozac, as both substances may amplify the effects of the other, increasing the risk for overdose and other potentially dangerous side effects. Drinking alcohol while taking Prozac can also interfere with treatment for depression and/or anxiety. Drinking alcohol while taking Prozac can potentially make these side effects worse. Long-Term Effects Of Mixing Alcohol And Prozac. While no long-term effects have been found through research or studies, this doesn’t mean that long-term effects don’t exist. It’s very possible for the effects of mixing Prozac and alcohol to worsen over time. Prozac Increases the Effect of Alcohol. Patients who are on Prozac are sometimes told that they can have about 3 drinks. What they need to be told is that antidepressants potentiate the effect of alcohol and 3 drinks is actually like 6 drinks. The liver breaks down all substances in order to make it non-toxic for the body. Those who consume a. Alcohol use is associated with negative coping skills: Reaching for alcohol as a way to cope with depression can lead to severe drinking problems, including alcohol addiction. Key Points: Prozac and Alcohol. The goal of taking Prozac as prescribed by a medical professional is to improve a mental health condition that a person may be struggling with. All these effects can be caused by Prozac or alcohol individually if they are consumed in high amounts, so mixing the two agents together will naturally lead to more side effects and greater dangers. Do so at your own discretion and consult a doctor before or after you decide to mix fluoxetine with alcohol. Alcohol can also keep Prozac from working as well as it should. Taking antidepressants like Prozac doesn’t mean you’re immune to the depressive effects of alcohol. Instead, alcohol may.